Enzymes and enzyme activity : structure, biology and clinical significance / Eva M. Lashinski, editor.

Includes bibliographical references and index.

Print version record.

ENZYMES AND ENZYMEACTIVITY ; ENZYMES AND ENZYMEACTIVITY ; Contents ; Preface ; Myeloperoxidase -- A Paradoxical Enzyme -- From Host Defense to Disease ; Abstract ; 1. Introduction ; 2. MPO Structure ; 3. MPO Catalytic Cycle ; 3.1. MPO Substrates ; 3.1.1. Substrates in the Halogenating Cycle of MPO ; 3.1.2. Substrates for the Peroxidase Cycle of MPO ; 4. MPO in Health; 5. MPO Related Diseases ; 5.1. Disorders Related to MPO-Oxidation Products ; 5.1.1. MPO Deficiency ; 5.1.2. MPO Overexpression ; MPO in Cancer ; MPO in Renal Injury; MPO in Inflammatory Vascular Disease.

MPO and Neurodegeneration MPO in Other Chronic Inflammatory Disorders ; 5.2. Direct Inflammatory Properties of MPO ; 6. Therapeutic Implications ; 6.1. MPO as a Biomarker ; 6.2. Target for Drug Development (Inhibitors of MPO) ; 6.3. MPO Degradation of Carbon Nanotubes ; Conclusion ; References ; Monitoring the Activation of Calpain I for Sensitive Assessment of Pathogenesisand Neuroprotectant Action ; Abstract ; Introduction ; Normal vs. Over-Activation of Calpain ; Hippocampal Slice Model of Excitotoxicity ; Models of Excitotoxin Exposure; Hypoxic and Ischemia Injury.

Traumatic Brain and Spinal InjuryHemorrhage and Vasospasm ; Aging and Aging Models; Example of Neuroprotectant Assessment ; Neuroprotection in the Hippocampal Slice Model ; Neuroprotection In Vivo; Conclusion ; Acknowledgments ; References ; Calpain: Structure, Biology and Clinical Significance ; Abstract ; Introduction ; Calpain Structure ; Calpain Activation ; Calpains Regulation; Role of Calpains in Muscle ; Biology and Clinical Significance ; Calpains in Muscle Pathology ; Calpains in Human Diseases ; Calpains and Non-Insulin Dependent Diabetes Mellitus (IDDM) ; Conclusion.

Acknowledgement References ; Calpain as Indicator of Organophosphorus-InducedDelayed Neuropathy ; Abstract ; Introduction ; Role of Calpain in a Normal Cell ; Organophosphorus Pesticides ; The Organophosphorus Intoxication ; Cholinergic Syndrome ; Intermediate Syndrome; Chronic Organophosphorus-Induced Neuropsychiatric Disorders; Organophosphorus-Induced Delayed Neuropathy ; Neuropathy Target Esterase ; Wallerian Degeneration ; References ; Biological Effects of CalpainInhibitors on Human Phagocyte Functions ; Abstract ; Abbreviations ; Introduction ; Neutrophil Apoptosis and Calpains.

Neutrophil Migration and Calpain Inhibitors Monocyte Migration and Calpain Inhibitors ; Calpain Inhibitors Activate Human Formyl Peptide Receptors ; Homology Modeling of Human Formyl Peptide Receptors and Ligand Docking Simulation ; Conclusion ; Disclosure ; References ; ALDH Activity of Artemia As a Tool for the Investigation of the Toxicityof Antifouling Paints ; Abstract ; 1. Introduction ; 2. Materials and Methods ; 2.1 Antifouling Paint ; 2.2. Artificial Seawater; 2.3. Test Vessels ; 2.4 Test Organisms ; 2.5. Antifouling Paint Toxicity Determination.

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