TY  - GEN
AU  - Nakagawa-Goto,Kyoko
AU  - Nakagawa-Goto,Kyoko
TI  - Antitumor and Anti-HIV Agents from Natural Products
SN  - books978-3-03943-009-3
PY  - 2020///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - natural phaeosphaeride A
KW  - antitumor activity
KW  - human tumor cell lines
KW  - HEF cell line
KW  - acute toxicity
KW  - aspidosperma-type
KW  - monoterpenoid indole alkaloids
KW  - antiproliferative activity
KW  - tubulin inhibitor
KW  - Bousigonia mekongensis
KW  - ursolic acid
KW  - DOTA
KW  - triterpenoids
KW  - cytotoxicity
KW  - diterpenoid alkaloids
KW  - human tumor cells
KW  - lipojesaconitine
KW  - delcosine
KW  - delpheline
KW  - kobusine
KW  - pseudokobusine
KW  - BRAF inhibitor
KW  - Mentha aquatica var. Kenting Water Mint
KW  - essential oil
KW  - chemoprevention
KW  - two-stage skin carcinogenesis
KW  - melanoma
KW  - curcumin analog
KW  - apoptosis
KW  - oxidative stress
KW  - drug-drug interaction
KW  - tamoxifen
KW  - taxol
KW  - cisplatin
KW  - Artemisia absinthium L
KW  - antioxidants
KW  - total phenolic content
KW  - melanoma and breast cancer cell line
KW  - HaCaT cells
KW  - inflammation
KW  - breast cancer
KW  - cell cycle
KW  - flavonoids
KW  - reactive oxygen species
KW  - tumor suppression
KW  - antiretroviral agents
KW  - anti-HIV
KW  - marine metabolites
KW  - natural products
KW  - drug development
KW  - Ivalin
KW  - Carpesium divaricatum
KW  - hepatocellular carcinoma
KW  - mitochondria-mediated apoptosis
KW  - NF-κB
KW  - Hernandia nymphaeifolia
KW  - butanolides
KW  - lignan glycosides
KW  - coumarins
KW  - antiangiogenic
KW  - cancer
KW  - natural agents
KW  - chemistry
KW  - medicine
KW  - cancer stem cell
KW  - cervical cancer
KW  - pterostilbene
KW  - resveratrol
KW  - caffeic acid
KW  - cancer multidrug resistance
KW  - P-glycoprotein
KW  - phenolic acid
KW  - oxypeucedanin
KW  - Angelica dahurica
KW  - antiproliferation
KW  - G2/M phase cell cycle arrest
KW  - p53
KW  - SK-Hep-1
KW  - hepatoma cells
KW  - allyl isothiocyanate
KW  - benzyl isothiocyanate
KW  - sulforaphane
KW  - phenethyl isothiocyanate
KW  - bladder cancer
KW  - quercetin
KW  - oral squamous cell carcinoma cells
KW  - metastasis
KW  - cell cycle arrest
KW  - epithelial-to-mesenchymal transition
KW  - matrix metalloproteinase
KW  - transforming growth factor-β1
KW  - β-lapachone
N1  - Open Access
N2  - Cancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered
UR  - https://mdpi.com/books/pdfview/book/2856
UR  - https://directory.doabooks.org/handle/20.500.12854/69087
ER  -