TY  - GEN
AU  - van Echten-Deckert,Gerhild
AU  - van Echten-Deckert,Gerhild
TI  - Sphingolipids : From Pathology to Therapeutic Perspectives - A Themed Honorary Issue to Prof. Lina Obeid
SN  - books978-3-03943-958-4
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - Biology, life sciences
KW  - S1P receptor
KW  - inflammation
KW  - S1P transporter
KW  - spinster homolog 2
KW  - barrier dysfunction
KW  - anxiety
KW  - depression
KW  - sphingolipids
KW  - sphingomyelinase
KW  - ceramidase
KW  - Smpd1
KW  - acid sphingomyelinase
KW  - forebrain
KW  - depressive-like behavior
KW  - anxiety-like behavior
KW  - ceramide
KW  - ceramides
KW  - ceramidases
KW  - neurodegenerative diseases
KW  - infectious diseases
KW  - sphingosine 1-phoshate
KW  - sphingosine 1-phosphate receptor
KW  - S1P1-5
KW  - sphingosine 1-phosphate metabolism
KW  - sphingosine 1-phosphate antagonistst/inhibitors
KW  - sphingosine 1-phosphate signaling
KW  - stroke
KW  - multiple sclerosis
KW  - neurodegeneration
KW  - fingolimod
KW  - Sphingosine-1-phosphate
KW  - obesity
KW  - type 2 diabetes
KW  - insulin resistance
KW  - pancreatic β cell fate
KW  - hypothalamus
KW  - sphingosine-1-phosphate
KW  - ischemia/reperfusion
KW  - cardioprotection
KW  - vasoconstriction
KW  - coronary flow
KW  - myocardial function
KW  - myocardial infarct
KW  - albumin
KW  - type 1 diabetes
KW  - beta-cells
KW  - islets
KW  - insulin
KW  - cytokines
KW  - S1P
KW  - animal models
KW  - cystic fibrosis
KW  - autophagy
KW  - myriocin
KW  - Aspergillus fumigatus
KW  - CLN3 disease
KW  - Cln3Δex7/8 mice
KW  - flupirtine
KW  - allyl carbamate derivative
KW  - apoptosis
KW  - cancer
KW  - gangliosides
KW  - immunotherapy
KW  - metastasis
KW  - phenotype switching
KW  - sphingosine 1-phosphate
KW  - Sphingosine 1-phosphate (S1P)
KW  - S1P-lyase (SGPL1)
KW  - tau
KW  - calcium
KW  - histone acetylation
KW  - hippocampus
KW  - cortex
KW  - astrocytes
KW  - neurons
KW  - sphingosine kinase
KW  - G-protein-coupled receptors
KW  - Gαq/11
KW  - n/a
KW  - sphingosine kinase 1
KW  - SK1
KW  - microRNA
KW  - transcription factor
KW  - hypoxia
KW  - long non-coding RNA
N1  - Open Access
N2  - Although sphingolipids are ubiquitous components of cellular membranes, their abundance in cells is generally lower than glycerolipids or cholesterol, representing less than 20% of total lipid mass. Following their discovery in the brain-which contains the largest amounts of sphingolipids in the body-and first description in 1884 by J.L.W. Thudichum, sphingolipids have been overlooked for almost a century, perhaps due to their complexity and enigmatic nature. When sphingolipidoses were discovered, a series of inherited diseases caused by enzyme mutations involved in sphingolipid degradation returned to the limelight. The essential breakthrough came decades later, in the 1990s, with the discovery that sphingolipids were not just structural elements of cellular membranes but intra- and extracellular signaling molecules. It turned out that their lipid backbones, including ceramide and sphingosine-1-phosphate, had selective physiological functions. Thus, sphingolipids emerged as essential players in several pathologies including cancer, diabetes, neurodegenerative disorders, and autoimmune diseases. The present volume reflects upon the unexpectedly eclectic functions of sphingolipids in health, disease, and therapy. This fascinating lipid class will continue to be the subject of up-and-coming future discoveries, especially with regard to new therapeutic strategies
UR  - https://mdpi.com/books/pdfview/book/4051
UR  - https://directory.doabooks.org/handle/20.500.12854/76606
ER  -