TY  - GEN
AU  - Serra,Raffaele
AU  - Serra,Raffaele
TI  - Matrix Metalloproteinases in Health and Disease
SN  - books978-3-03943-053-6
PY  - 2020///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Humanities
KW  - bicssc
KW  - Social interaction
KW  - hypersensitivity pneumonitis
KW  - metalloproteinases
KW  - genetic association
KW  - autoantibodies
KW  - MMP1
KW  - MMP2
KW  - SNPs
KW  - MMPs
KW  - TIMPs
KW  - CKD
KW  - peripheral vascular disease
KW  - biomarkers
KW  - proteinuria
KW  - eGFR
KW  - PAD
KW  - NGAL
KW  - statins
KW  - arterial aneurysms
KW  - patients
KW  - collagenases
KW  - Crohn's disease
KW  - dental caries
KW  - mouth
KW  - periodontitis
KW  - matrix metalloproteinase-9
KW  - dialysis
KW  - on-line hemodiafiltration
KW  - high-flux dialysis
KW  - renal replacement therapy
KW  - kidney transplantation
KW  - Mac-1
KW  - CD147
KW  - leukocytes
KW  - platelets
KW  - adhesion
KW  - integrin αMβ2
KW  - matrix metalloproteinases
KW  - TIMP
KW  - synthetic inhibitors
KW  - RECK
KW  - matrix metalloproteinase
KW  - MAPKs
KW  - ischemia/reperfusion
KW  - eNOS
KW  - iNOS
KW  - inflammatory bowel disease
KW  - inflammation
KW  - NO
KW  - MMP-9
KW  - cGMP
KW  - Caco-2
KW  - matrix metalloproteinase-7
KW  - fibrosis
KW  - acute kidney injury
KW  - chronic kidney disease
KW  - apoptosis
KW  - health
KW  - disease
N1  - Open Access
N2  - Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual's disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems
UR  - https://mdpi.com/books/pdfview/book/2831
UR  - https://directory.doabooks.org/handle/20.500.12854/69062
ER  -