TY  - GEN
AU  - Kreider,Richard B.
AU  - Stout,Jeffrey
AU  - Kreider,Richard B.
AU  - Stout,Jeffrey
TI  - Creatine Supplementation for Health and Clinical Diseases
SN  - books978-3-0365-2156-5
PY  - 2022///
CY  - Basel
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - Biology, life sciences
KW  - Food & society
KW  - ergogenic aids
KW  - cellular metabolism
KW  - phosphagens
KW  - sarcopenia
KW  - cognition
KW  - diabetes
KW  - creatine synthesis deficiencies
KW  - concussion
KW  - traumatic brain injury
KW  - spinal cord injury
KW  - muscle atrophy
KW  - rehabilitation
KW  - pregnancy
KW  - immunity
KW  - anti-inflammatory
KW  - antioxidant
KW  - anticancer
KW  - creatine
KW  - nutritional supplements
KW  - fertility
KW  - newborn
KW  - development
KW  - brain injury
KW  - post-viral fatigue syndrome
KW  - chronic fatigue syndrome
KW  - GAA
KW  - creatine kinase
KW  - dietary supplements
KW  - exercise
KW  - skeletal muscle
KW  - glycemic control
KW  - type 2 diabetes mellitus
KW  - phosphorylcreatine
KW  - dietary supplement
KW  - ergogenic aid
KW  - youth
KW  - athletes
KW  - osteoporosis
KW  - osteosarcopenia
KW  - frailty
KW  - cachexia
KW  - innate immunity
KW  - adaptive immunity
KW  - inflammation
KW  - macrophage polarization
KW  - cytotoxic T cells
KW  - toll-like receptors
KW  - vascular pathology
KW  - cardiovascular disease
KW  - oxidative stress
KW  - vascular health
KW  - female
KW  - menstrual cycle
KW  - hormones
KW  - exercise performance
KW  - menopause
KW  - mood
KW  - children
KW  - height
KW  - BMI-for-age
KW  - stature-for-age
KW  - growth
KW  - phosphocreatine
KW  - creatine transporter
KW  - supplementation
KW  - treatment
KW  - heart
KW  - heart failure
KW  - ischemia
KW  - myocardial infarction
KW  - anthracycline
KW  - cardiac toxicity
KW  - energy metabolism
KW  - cell survival
KW  - bioinformatics
KW  - systems biology
KW  - cellular allostasis
KW  - dynamic biosensor
KW  - pleiotropic effects of creatine (Cr) supplementation
KW  - inflammatory bowel diseases (IBD)
KW  - ulcerative colitis
KW  - Crohn's disease
KW  - creatine kinase (CK)
KW  - phosphocreatine (PCr)
KW  - creatine transporter (CrT)
KW  - intestinal epithelial cell protection
KW  - intestinal tissue protection
KW  - creatine perfusion
KW  - organ transplantation
KW  - Adenosine mono-phosphate (AMP)
KW  - activated protein kinase (AMPK)
KW  - liver kinase B1 (LKB1)
KW  - mitochondrial permeability transition pore (mPTP)
KW  - reactive oxygen species (ROS)
KW  - glucose transporter (GLUT)
KW  - T cell antitumor immunity
KW  - metabolic regulator
KW  - cancer immunotherapy
KW  - supplements
KW  - muscle damage
KW  - recovery
KW  - immobilization
KW  - atrophy
KW  - muscular dystrophy
KW  - amyotrophic lateral sclerosis
KW  - Parkinson's Disease
KW  - cardiopulmonary disease
KW  - mitochondrial cytopathy
KW  - hypertrophy
KW  - athletic performance
KW  - weightlifting
KW  - resistance exercise
KW  - training
KW  - muscular power
KW  - muscular adaptation
KW  - muscle fatigue
KW  - adipose tissue
KW  - muscle strength
KW  - physiological adaptation
KW  - mitochondria
KW  - thermogenesis
KW  - MAP kinase signaling system
KW  - sodium-chloride-dependent neurotransmitter symporters
KW  - signal transduction
KW  - intradialytic creatine supplementation
KW  - hemodialysis
KW  - muscle
KW  - protein energy wasting
KW  - clinical trial
KW  - muscle weakness
KW  - chronic fatigue
KW  - cognitive impairment
KW  - depression
KW  - anemia
KW  - resistance training
KW  - sports nutrition
KW  - strength
KW  - toxicity
KW  - methylation
KW  - hyperhomocysteinemia
KW  - neuromodulation
KW  - MCDA
KW  - mitochondriopathia
KW  - cardiac infarction
KW  - long COVID
KW  - hypoxia
KW  - stroke
KW  - neurodegenerative diseases
KW  - noncommunicable disease
KW  - adenosine 5'-monopnophosphate-activated protein kinase
KW  - anthracyclines
KW  - creatine supplementation
KW  - cardiac signaling
KW  - cardiotoxicity
KW  - doxorubicin
KW  - soy
KW  - vegetarian/vegan diet
KW  - amino acids
KW  - dietary ingredients
KW  - performance
N1  - Open Access
N2  - Creatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states.  Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue
UR  - https://mdpi.com/books/pdfview/book/5131
UR  - https://directory.doabooks.org/handle/20.500.12854/81102
ER  -