TY - BOOK AU - Hein,Jotun AU - Schierup,Mikkel H. AU - Wiuf,Carsten TI - Gene genealogies, variation and evolution: a primer in coalescent theory SN - 1423770803 AV - QH438.4.M3 H456 2005eb U1 - 576.5/8/015118 22 PY - 2005/// CY - Oxford, New York PB - Oxford University Press KW - Population genetics KW - Mathematical models KW - Gene mapping KW - Genetics KW - Genetics, Population KW - Chromosome Mapping KW - Models, Genetic KW - Génétique KW - Modèles mathématiques KW - Génétique des populations KW - Cartes chromosomiques KW - SCIENCE KW - Life Sciences KW - Genetics & Genomics KW - bisacsh KW - fast KW - Evolution KW - gnd KW - Genanalyse KW - Mathematisches Modell KW - Populationsgenetik KW - Rekombination KW - Genetik KW - Koaleszenz KW - Populatiegenetica KW - gtt KW - Coalescentie KW - Variaties KW - Biometrie KW - Genetica de populacʹoes (modelos matematicos) KW - larpcal KW - Genetica (evolucʹao) KW - nucleotidenvolgordes KW - nucleotide sequences KW - dna sequencing KW - genetische variatie KW - genetic variation KW - genetische diversiteit KW - genetic diversity KW - populatiegenetica KW - population genetics KW - gegevensanalyse KW - data analysis KW - waarschijnlijkheidstheorie KW - probability theory KW - Population and Quantitative Genetics KW - Kwantitatieve- en populatiegenetica KW - Electronic books N1 - Includes bibliographical references (pages 259-271) and index; The basic coalescent --; A Y-chromosome data set --; Data and theory --; The Wright-Fisher model --; Assumptions of the Wright-Fisher model --; The number of descendants of a gene in one generation --; The geometric distribution --; The exponential distribution --; The discrete-time coalescent --; Coalescence of a sample of two genes --; Coalescence of a sample of n genes --; Example: Effect of approximations --; The continuous time coalescent --; Calculating simple quantities on a coalescent tree --; The height of a tree --; The total branch length of a tree --; The effect of sampling more sequences --; The effective population size --; The Moran model --; Robustness of the coalescent --; From genealogies to sequences --; Mathematical models of alleles --; The infinite alleles model --; The infinite sites model --; Finite sites model --; The Wright-Fisher model with mutation --; Algorithms for simulating sequence evolution --; The probability of a sample configuration --; Infinite alleles model --; Infinite sites model --; Impossible ancestral states --; Quantities related to the infinite sites model --; The number of segregating sites --; Haplotypes --; Pairwise mismatch distribution --; Estimators of [theta] and Tajima's D --; Evolutionary versus sampling variance --; Example 1: The variable S[subscript n] --; Example 2: Tajima's estimator [pi] --; Trees and topologies --; Some terminology --; The jump process and the waiting time process --; The coalescent and phylogenetic trees --; Counting trees and topologies --; Gene trees --; How to build a gene tree N2 - "This text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Authored by leading experts, and rich in examples and illustrations, Gene Genealogies, Variation and Evolution is highly suitable for a graduate course in statistics; population, molecular and medical genetics; and for bioscience and medicine and students studying the evolution of human population and disease. It is also a reference for bioscientists and statisticians in the pharmaceutical industry and academia."--Jacket UR - https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=159132 ER -