Alpha-fetoprotein : functions and clinical application / editors, Nisha Lakhi and Michael Moretti (Department of Department of Obstetrics and Gynaecology, Richmond University Medical Centre, Staten Island, New York, USA).

Includes index.

Print version record and CIP data provided by publisher.

ALPHA-FETOPROTEIN FUNCTIONS AND CLINICAL APPLICATIONS; ALPHA-FETOPROTEIN FUNCTIONS AND CLINICAL APPLICATIONS; Library of Congress Cataloging-in-Publication Data; CONTENTS; FOREWORD AN OVERVIEW OF ALPHA-FETOPROTEIN RESEARCH THROUGHOUT THE DECADES; PREFACE; SECTION 1: ALPHA-FETOPROTEIN HISTORY AND NORMAL AND PATHOLOGICAL DEVELOPMENT; Chapter 1: THE HISTORY OF ALPHA-FETOPROTEIN DISCOVERY; ABSTRACT; INTRODUCTION; THE HISTORY OF ALPHA-FETOPROTEIN DISCOVERY; The First Ideas; THE MAIN SCIENTIFIC RESEARCHERS ENGAGED IN INVESTIGATION ON AFP FROM RUSSIA; INVESTIGATION ABOUT AFP IN THE WORLD

MOLECULAR ANALYSES OF AFP IN LAST PERIODCONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: ALPHA-FETOPROTEIN IN DEVELOPMENT, AFTER LIVER INJURY, DURING CHEMICAL HEPATOCARCINOGENESIS AND IN LIVER CANCER: HOW THE STUDY OF ALPHA-FETOPROTEIN LED TO THE CONCEPT OF CANCER STEM CELLS; ABSTRACT; INTRODUCTION; Radioimmunoassay for AFP; AFP in Development; AFP IN RESTITUTIVE PROLIFERATION; Partial Hepatectomy (PH); Galactosamine; Allyl Alcohol (AA); Chemical Hepatocarcinogenesis; Diethylnitrosamine (DEN); Acetylaminofluorene-CCl4; Cyclic AAF; AFP Production by Hepatomas; Function of AFP; REFERENCES

Chapter 3: THE ROLE OF ALPHA-FETOPROTEIN IN HUMAN HEPATOCELLULAR CARCINOMAABSTRACT; INTRODUCTION; 1. BIOLOGICAL CHARACTERISTICS OF AFP; 1.1. Biological Functions of AFP; 2.1. AFP Is Involved in Multiple Signaling Transduction Pathways; 2. AFP IS INVOLVED IN IMMUNOSUPPRESSION PROCESS; 2.3. AFP Has Dual-Directional Regulation Effect in Cell ProliferationProcess; 3. CLINICAL USE OF AFP; REFERENCES; Chapter 4: USE OF ALPHA-FETOPROTEIN AND OTHER BIOMARKERS FOR ASSESSING HEPATOCELLULAR CARCINOMA RISK IN VIRAL HEPATITIS; ABSTRACT; INTRODUCTION

ROLE OF CURRENTLY AVAILABLE BIOMARKERS AND THEIR UTILIZATION IN HCC MANAGEMENTALPHA-FETOPROTEIN; AFP for Surveillance of CHB Patients; AFP for Surveillance of Patients with Chronic Hepatitis C; AFP as Prognostic Indicator for Outcomes after the Diagnosis of HCC; AFP for Allocation of Liver Organ for Liver Transplantation; AFP-L3%; DCP; OSTEOPONTIN; GLYPICAN; GOLGI PROTEIN 73; FIBROBLAST GROWTH FACTOR (FGF) AMPLIFICATION; CANAVANINOSUCCINATE; FIVE GENE SCORE; HIGH MET EXPRESSION; CONCLUSION; REFERENCES

Chapter 5: ALPHA-FETOPROTEIN IN A PROTEIN INTERACTION NETWORK: SYSTEMS BIOLOGY APPROACH IN DISCOVERY BIOMARKERS FOR HEPATOCELLULAR CARCINOMAABSTRACT; INTRODUCTION; BIOMARKER PROFILING TECHNOLOGIES; ALPHA-FETOPROTEIN IN COMBINED TESTING FOR HCC; KNOWN MOLECULAR FUNCTIONS OF HCC BIOMARKERS; EVALUABILITY OF NETWORK ANALYSIS IN HCC; CONCLUSION; REFERENCES; Chapter 6: ALPHA-FETOPROTEIN IN MALIGNANT PEDIATRIC TUMORS; ABSTRACT; INTRODUCTION; GERM CELL TUMORS; HEPATOBLASTOMA AND HEPATOCELLULAR CARCINOMA; AFP AND ASSOCIATED RARE PEDIATRIC SOLID CANCERS; CONCLUSION; REFERENCES

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