Acquired brain injury in the fetus and newborn / edited by Michael Shevell and Steven P. Miller.

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Authors' Appointments; Foreword; Preface; Acknowledgments; 1 Brain Injury in the Fetus; Introduction; Overview of normal fetal brain development; Normal function of the maternal placenta-fetalinterface; Mechanisms of fetal brain injury; Fetal errors of metabolism; Conclusions; 2 Imaging the Fetal Brain; Introduction; Imaging the fetal brain: ultrasound versus magneticresonance imaging; Imaging the fetal brain: the role of conventionalmagnetic resonance imaging; Normal fetal brain development on conventionalmagnetic resonance imaging.

Fetal brain injury in the fetus on conventionalmagnetic resonance imagingAdvanced magnetic resonance imaging techniques inthe ex utero infant; Acquired fetal brain injury and advanced in vivofetal magnetic resonance imaging techniques; Summary; 3 Mechanisms of Acute and Chronic Brain Injury in the Preterm Infant ; Magnitude of the problem and spectrum of braininjury in preterm survivors; Patholologic features of brain injury in preterminfants; Pathophysiology of cerebral white matter injury; Cellular-molecular mechanisms of acute whitematter injury.

Cellular mechanisms of chronic white matterinjury: myelination failure and the susceptibility ofoligodendrocytes and axonsIs acquired chronic brain injury in preterm infantsnecessarily static and irreparable?; Clinical implications of potentially arrested whitematter development; 4 Clinical assessment of the Preterm Infantincluding Near-infrared spectroscopy, amplitude-integrated Electroencephalography, and Electroencephalography; Near-infrared spectroscopy-monitored regionalcerebral oxygen saturation; Electroencephalography and amplitude-integratedEEG; Conclusion.

5 Imaging the Brain of the Preterm InfantIntroduction; Magentic resonance imaging of the brain in thenormal preterm infant; Magnetic resonance imaging of brain injury in thepreterm infant; Quantitative magnetic resonance studies ofthe developing brain in the preterm infant andassociation with neurodevelopmental outcome; 6 Protecting the Brain of the Preterm Infant; Introduction; Intraventricular hemorrhage; Posthemorrhagic ventricular dilation; White matter injury; Cerebellar injury; Antenatal neuroprotective agents; Developmental care and nutrition.

Emerging candidates for future neuroprotectiveinvestigationsConclusions; 7 Seizures in the Preterm Infant; Introduction; Epidemiology; Clinical features; Differential diagnosis; Investigations including imaging; Treatment and management; Short- and long-term outcomes; Implications for future research; 8 Outcomes After Brain Injury in the Preterm Infant; Motor impairment; Cognitive impairment; Behavioral and psychiatric disorders; Conclusion; 9 Mechanisms of Brain Neurodegeneration inthe Term Infa nt; Introduction; Types of cell death.

Expert synthesis of acquired brain injuries from the fetus to the term newborn to improve diagnosis and care is presented in this authoritative book, including recent significant advances. This book focuses on specific populations encountered regularly by clinicians, practising neurologists, neonatologists and paediatricians.

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