MARC details
| 000 -LEADER |
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| fixed length control field |
05445naaaa2201333uu 4500 |
| 001 - CONTROL NUMBER |
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| control field |
https://directory.doabooks.org/handle/20.500.12854/76606 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20220714193945.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
books978-3-03943-958-4 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783039439577 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783039439584 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.3390/books978-3-03943-958-4 |
| Terms of availability |
doi |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
dc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
GP |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
PS |
| Source |
bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
van Echten-Deckert, Gerhild |
| Relator code |
edt |
| 9 (RLIN) |
1620547 |
| 245 10 - TITLE STATEMENT |
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| Title |
Sphingolipids : From Pathology to Therapeutic Perspectives - A Themed Honorary Issue to Prof. Lina Obeid |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
Basel, Switzerland |
| Name of publisher, distributor, etc |
MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 electronic resource (292 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE |
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| Terms governing access |
Open Access |
| Source of term |
star |
| Standardized terminology for access restriction |
Unrestricted online access |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Although sphingolipids are ubiquitous components of cellular membranes, their abundance in cells is generally lower than glycerolipids or cholesterol, representing less than 20% of total lipid mass. Following their discovery in the brain-which contains the largest amounts of sphingolipids in the body-and first description in 1884 by J.L.W. Thudichum, sphingolipids have been overlooked for almost a century, perhaps due to their complexity and enigmatic nature. When sphingolipidoses were discovered, a series of inherited diseases caused by enzyme mutations involved in sphingolipid degradation returned to the limelight. The essential breakthrough came decades later, in the 1990s, with the discovery that sphingolipids were not just structural elements of cellular membranes but intra- and extracellular signaling molecules. It turned out that their lipid backbones, including ceramide and sphingosine-1-phosphate, had selective physiological functions. Thus, sphingolipids emerged as essential players in several pathologies including cancer, diabetes, neurodegenerative disorders, and autoimmune diseases. The present volume reflects upon the unexpectedly eclectic functions of sphingolipids in health, disease, and therapy. This fascinating lipid class will continue to be the subject of up-and-coming future discoveries, especially with regard to new therapeutic strategies. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
Creative Commons |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| -- |
cc |
| -- |
https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Research & information: general |
| Source of heading or term |
bicssc |
| 9 (RLIN) |
928234 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Biology, life sciences |
| Source of heading or term |
bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
S1P receptor |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
inflammation |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
S1P transporter |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
spinster homolog 2 |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
barrier dysfunction |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
anxiety |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
depression |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingolipids |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingomyelinase |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
ceramidase |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Smpd1 |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
acid sphingomyelinase |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
forebrain |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
depressive-like behavior |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
anxiety-like behavior |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
ceramide |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
ceramides |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ceramidases |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurodegenerative diseases |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
infectious diseases |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingosine 1-phoshate |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingosine 1-phosphate receptor |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
S1P1-5 |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingosine 1-phosphate metabolism |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingosine 1-phosphate antagonistst/inhibitors |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
sphingosine 1-phosphate signaling |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
stroke |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
multiple sclerosis |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
neurodegeneration |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
fingolimod |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Sphingosine-1-phosphate |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
obesity |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
type 2 diabetes |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
insulin resistance |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
pancreatic β cell fate |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
hypothalamus |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
sphingosine-1-phosphate |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
ischemia/reperfusion |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cardioprotection |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
vasoconstriction |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
coronary flow |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
myocardial function |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
myocardial infarct |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
albumin |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
type 1 diabetes |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
beta-cells |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
islets |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
insulin |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cytokines |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
S1P |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
animal models |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
cystic fibrosis |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
autophagy |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
myriocin |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Aspergillus fumigatus |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
CLN3 disease |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cln3Δex7/8 mice |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
flupirtine |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
allyl carbamate derivative |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
apoptosis |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
cancer |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
gangliosides |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
immunotherapy |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
metastasis |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
phenotype switching |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingosine 1-phosphate |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Sphingosine 1-phosphate (S1P) |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
S1P-lyase (SGPL1) |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
tau |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
calcium |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
histone acetylation |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
hippocampus |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
cortex |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
astrocytes |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
neurons |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingosine kinase |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
G-protein-coupled receptors |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Gαq/11 |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
n/a |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
sphingosine kinase 1 |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
SK1 |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
microRNA |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
transcription factor |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
hypoxia |
| 653 ## - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
long non-coding RNA |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
van Echten-Deckert, Gerhild |
| Relator code |
oth |
| 9 (RLIN) |
1620547 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://mdpi.com/books/pdfview/book/4051">https://mdpi.com/books/pdfview/book/4051</a> |
| -- |
0 |
| Public note |
DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Host name |
www.oapen.org |
| Uniform Resource Identifier |
<a href="https://directory.doabooks.org/handle/20.500.12854/76606">https://directory.doabooks.org/handle/20.500.12854/76606</a> |
| -- |
0 |
| Public note |
DOAB: description of the publication |
