3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant
Pellicano, Rinaldo
3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 - 1 electronic resource (236 p.)
Open Access
We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence. Nevertheless, the opportunities to understand the role of these microorganisms in human diseases and to design a potential treatment were limited. At present, thanks to development of innovative and cutting-edge molecular biological and microbiological technologies as well as clinical informatics and bioinformatics skills, microbiome application is moving into clinics. Approaches to therapy based on prebiotics, probiotics and lately on fecal microbiota transplantation has revolutionized medicine. Microbiota outnumbers our genes and is now regarded as another organ of the body. The gastrointestinal tract and gut microbiota display a well-documented symbiotic relationship. Disruption of intestinal microbiota homeostasis-called dysbiosis-has been associated with several diseases. Whether dysbiosis is a cause or consequence of disease initiation and progression still needs to be investigated in more depth. The aim of this book is to highlight recent advances in the field of microbiome research, which are now shaping medicine, and current approaches to microbiome-oriented therapy for gastrointestinal diseases. Dr. Rinaldo Pellicano Dr. Sharmila Fagoonee Guest Editors
Creative Commons
English
books978-3-0365-2797-0 9783036527963 9783036527970
10.3390/books978-3-0365-2797-0 doi
Public health & preventive medicine
Bacteroides ovatus Bifidobacterium adolescentis Dysbiosis Faecalibacterium prausnitzii Ruminococcus gnavus type 1 diabetes microbiota microbiome auto-immunity gut permeability gut IBS celiac disease enteropathy gluten therapy gut microbiota precision medicine Clostridium difficile inflammatory bowel disease ulcerative colitis irritable bowel disease metabolic syndrome gastric microbiota transient persistent culture sequencing Helicobacter pylori fecal microbiota transplantation feces donor fecal microbiota flow cytometry viability of bacteria next-generation sequencing culturing of fecal microbiota Alzheimer's disease microbiota-gut-brain axis neurodegenerative disease intestinal flora necrotizing enterocolitis intestinal microbiology infant gut metabolomics IL-6 IL-8 IL-12p70 intestinal permeability zonulin gut virome steatosis cirrhosis hepatocellular carcinoma gastrointestinal technology high-throughput crohn's disease mononuclear cells transient receptor potential channel pancreatic diseases acute pancreatitis chronic pancreatitis diabetes mellitus pancreatic ductal adenocarcinoma pancreatic cystic neoplasms
3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 - 1 electronic resource (236 p.)
Open Access
We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence. Nevertheless, the opportunities to understand the role of these microorganisms in human diseases and to design a potential treatment were limited. At present, thanks to development of innovative and cutting-edge molecular biological and microbiological technologies as well as clinical informatics and bioinformatics skills, microbiome application is moving into clinics. Approaches to therapy based on prebiotics, probiotics and lately on fecal microbiota transplantation has revolutionized medicine. Microbiota outnumbers our genes and is now regarded as another organ of the body. The gastrointestinal tract and gut microbiota display a well-documented symbiotic relationship. Disruption of intestinal microbiota homeostasis-called dysbiosis-has been associated with several diseases. Whether dysbiosis is a cause or consequence of disease initiation and progression still needs to be investigated in more depth. The aim of this book is to highlight recent advances in the field of microbiome research, which are now shaping medicine, and current approaches to microbiome-oriented therapy for gastrointestinal diseases. Dr. Rinaldo Pellicano Dr. Sharmila Fagoonee Guest Editors
Creative Commons
English
books978-3-0365-2797-0 9783036527963 9783036527970
10.3390/books978-3-0365-2797-0 doi
Public health & preventive medicine
Bacteroides ovatus Bifidobacterium adolescentis Dysbiosis Faecalibacterium prausnitzii Ruminococcus gnavus type 1 diabetes microbiota microbiome auto-immunity gut permeability gut IBS celiac disease enteropathy gluten therapy gut microbiota precision medicine Clostridium difficile inflammatory bowel disease ulcerative colitis irritable bowel disease metabolic syndrome gastric microbiota transient persistent culture sequencing Helicobacter pylori fecal microbiota transplantation feces donor fecal microbiota flow cytometry viability of bacteria next-generation sequencing culturing of fecal microbiota Alzheimer's disease microbiota-gut-brain axis neurodegenerative disease intestinal flora necrotizing enterocolitis intestinal microbiology infant gut metabolomics IL-6 IL-8 IL-12p70 intestinal permeability zonulin gut virome steatosis cirrhosis hepatocellular carcinoma gastrointestinal technology high-throughput crohn's disease mononuclear cells transient receptor potential channel pancreatic diseases acute pancreatitis chronic pancreatitis diabetes mellitus pancreatic ductal adenocarcinoma pancreatic cystic neoplasms